Table 2 Summary of TDP-43_SAA results
From: TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis
Patient group | TDP-43_SAA positive cases, % (n/N) | Lag-phase time, mean hours (SD)* | Last fluorescence value, mean AUs (SD)* |
|---|---|---|---|
Sporadic MND | |||
 sALS | 43% (15/35) | 23.4 (8.2) | 227 933 (51 694) |
 bALS | 39% (7/18) | 23.0 (10.1) | 180 887 (82 122) |
 PLS | 60% (6/10) | 18.9 (11.8) | 173 091 (89 048) |
 FOSMN | 50% (1/2) | 30.5 (NA) | 217 558 (NA) |
Genetic MND | |||
 C9orf72exp | 50% (3/6) | 27.8 (3.8) | 260 000 (0) |
 TARDBP | 50% (2/4) | 30.2 (1.8) | 234 936 (35 446) |
 SQSTM1 | 67% (2/3) | 19.2 (18.7) | 256 962 (4 295) |
 C9orf72exp + SQSTM1 | 0% (0/1) | NA | NA |
 OPTN | 100% (1/1) | 20.0 (NA) | 260 000 (NA) |
 GLE1 | 100% (1/1) | 6.5 (NA) | 82 886 (NA) |
 FUS | 0% (0/1) | NA | NA |
 SOD1 | 0% (0/4) | NA | NA |
Other Neurodegenerative Diseases | |||
 MSA | 0% (0/6) | NA | NA |
 AD | 67% (2/3) | 5.7 (1.1) | 81 219 (13 158) |
 DLB | 50% (4/8) | 9.0 (1.5) | 60 091 (8 448) |
CTRLs | 14% (3/22) | 18.8 (12.0) | 79 319 (33 479) |