Fig. 5
From: TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis
αSyn_SAA results for OM samples from genetic MND cases. αSyn_SAA showed seeding activity in 1 C9orf72exp patient (dark blue curve), 2 SQSTM1 patients (light blue curves) and 1 TARDBP patient (green curve). No seeding activity was detected in C9orf72exp + SQSTM1, OPTN, GLE1, FUS or SOD1 cases (gray lines). Abbreviations: MND = motor neuron disease; C9orf72exp = chromosome 9 open reading frame 72 expansion; SQSTM1 = sequestosome 1; SOD1 = superoxide dismutase type 1; TARDBP = TAR DNA-binding protein; AU = arbitrary units; h = hours