Fig. 2
From: TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis
TDP-43_SAA results for OM samples from genetic MND cases. TDP-43_SAA showed seeding activity in 50% of TARDBP cases (green curves), 67% of SQSTM1 cases (light blue curves), 100% of OPTN (pink curve) and GLE1 cases (orange curve) and 50% of C9orf72exp cases (dark blue curves) (including a presymptomatic case, dotted dark blue curve). Gray lines indicate cases in which no seeding was observed. Abbreviations: MND = motor neuron disease; C9orf72 = chromosome 9 open reading frame 72; SQSTM1 = sequestosome 1; SOD1 = superoxide dismutase type 1; TARDBP = TAR DNA-binding protein; GLE1 = GLE1 RNA export mediator; OPTN = optineurin; AU = arbitrary units; h = hours