Fig. 5

Scatterplot illustrating the effect of αSyn SAA status on the association between amyloid-PET centiloid (A) and tau-PET (B) at baseline on subsequent change rates in the ADAS13 score of global cognition. Diagnostic groups are indicated by shape, the cut-point of amyloid-PET positivity is indicated by the dashed red line at 25 centiloids. Beta values indicate the strength of the amyloid-PET x CSF αSyn SAA interaction effect (A) or the tau-PET x CSF αSyn SAA interaction effect (B), as determined by linear regression, controlling for age, sex and study site and maximum follow up time of cognitive assessments. FDR-correction for multiple comparisons (p < 0.05) was applied for the main regression analyses, adjusting for five statistical tests