Fig. 7
From: SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
SIRT2 immunoreactivity is increased in GFAP-positive astrocytes of the hippocampus of AD patients. A Dot-plot representing average FPKM value obtained from transcriptomics of human post-mortem brain tissue. B Representative image of the hippocampal section from normal subject and AD patient. C Dot-plot representing Pearson’s coefficient of SIRT2 x GFAP colocalization in images from (D) (individual dot refers to one image). D Representative images of SIRT2 and GFAP immunoreactivity in the hippocampal regions (DG, CA1, CA2, CA3, and CA4) of human brain tissue. Black arrows indicate GFAP-positive astrocytes (brown), and white arrows indicate SIRT2 signals (red). E Densitometry analysis of SIRT2 immunoreactivity in GFAP-positive area from images in (D) of the corresponding hippocampal regions (individual dots represent ROIs corresponding to individual cell). Data represents Mean ± SEM. Data recorded from 4 samples in each condition, 10 cells per sample (Unpaired t-test)